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And today, I want to talk about one of those innovative approaches: a curious little peptide that has been studied for more than 40 years, particularly in the context of gut inflammation: KPV

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Abbreviations Abs: Apoptotic bodies A: Amyloid betaprotein AD: Alzheimers disease APTEMED: Ammonium persulphateN,N,N,N-Tetramethylethylenediamine BBB: Bloodbrain barrier BDNF: Brainderived neurotrophic factor bEnd.3: Brain microvascular endothelial cells BMn: Manganese dioxide nanozymes BSA: Bovine serum albumin BV2: Microglial cells C6: Coumarin6 CalceinAM: Calcein Acetoxymethyl Ester CAT: Catalase CCK8: Cell Counting Kit8 CLSM: Confocal laser scanning microscopy CNS: Central nervous system DCFHDA: 2',7'-Dichlorodihydrofluorescein diacetate DLS: Dynamic light scattering DMEM: Dulbecco's Modified Eagle Medium DMPO: 5,5dimethyl1pyrroline Noxide DOTAP: 1,2Dioleoyl3trimethylammoniumpropane ELISA: Enzymelinked immunosorbent assay ESR: Electron spin resonance EVs: Extracellular vesicles FBS: Fetal bovine serum FITC: Fluorescein Isothiocyanate FTIR: Fourier transform infrared spectroscopy H&E: Hemolysis assays, hematoxylineosin H 2 O 2 : Hydrogen peroxide HR: Hemolysis rate HRP: Horseradish peroxidase HT22: Hippocampal neurons cells IBA1: Ionized calciumbinding adapter molecule1 ICPOES: Inductively coupled plasma optical emission spectrometer KD: CD44-knockdown LLC cells LAbs: Apoptotic bodies derived from brain metastatic tumor cells LLC: Lewis lung carcinoma LPS: Lipopolysaccharide Mn: Manganese MWM: Morris water maze NFTs: Neurofibrillary tangles O 2 : Oxygen OA: Okadaic acid ptau: Phosphorylated tau Papp: Apparent permeability coefficient PBS: Phosphatebuffered saline PI: Propidium Iodide PS: Phosphatidylserine PVDF: Polyvinylideneuoride Rapa: Rapamycin RBC: Red blood cell ROS: Reactive oxygen species SDSPAGE: Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis SOD: Superoxide dismutase TEER: Transendothelial electrical resistance TEM: Transmission electron microscopy ThT: Thioflavin T TMB: 3,3',5,5'Tetramethylbenzidine UV: Ultraviolet WB: Western blot XPS: xray photoelectron spectroscopy XRD: xray diffraction 8OHG: 8hydroxyguanosine References Arvanitakis Z, Shah RC, Bennett DAJJ

By going to bed and waking up at roughly the same time each day, even on weekends, you help regulate your bodys natural circadian rhythm, making it easier to fall asleep and wake up feeling refreshed